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[alomone labs] Beyond Plaques: How Amyloid Precursor Protein Affects GABAergic Transmission

관리자 2023.07.21 14:58 조회 556 추천 4
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Beyond Plaques: How Amyloid Precursor Protein Affects GABAergic Transmission



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Research on Alzheimer's disease often focuses on amyloid beta plaques and mutations in the amyloid precursor protein (APP). But a new Belgian study explores how APP, in the absence of mutations or amyloid plaque formation, modulates excitatory and inhibitory neurotransmission.


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New Products

Membrane Protein Immunodetection

Primary Antibodies:

Anti-Nicotinic Acetylcholine Receptor α10 (CHRNA10) Antibody

Cat #: #ANC-010
Type: Polyclonal | Host: Rabbit | Applications: WB, *ICC, *IFC, *IHC, *IP |

Reactivity: M, R, *H


Guinea pig Anti-GIRK2 (Kir3.2) Antibody

Cat #: #APC-006-GP
Type: Polyclonal | Host: Guinea Pig | Applications: IF, IHC, WB,

*ICC, *IFC, *IP | Reactivity: M, R, *H




Antibodies for Live Cell Direct Flow Cytometry:

Anti-µ-Opioid Receptor (OPRM1) (extracellular)-ATTO Fluor-488 Antibody

Cat #: #AOR-011-AG
Type: Polyclonal | Host: Rabbit | Applications: FC, LCI, *ICC, *IHC |

Reactivity: H, M, R


Anti-5HT3B Receptor (HTR3B) (extracellular)-ATTO Fluor-488 Antibody

Cat #: ASR-032-AG
Type: Polyclonal | Host: Rabbit | Applications: FC, IF, IHC, *ICC, *LCI |

Reactivity: M, R


 

Ion Channel Pharmacology

Small Organic Molecules:

CP 465022 hydrochloride

Cat #: C-335
Type: Small Molecules | SourceSynthetic | MW: 499.4 |

Target: AMPA receptors, NaV1.6 Na+ channels


L-Quisqualic acid

Cat #: L-210
Type: Small Molecules | SourceSynthetic | MW: 189.1|

Target: AMPA receptors

 

N-Me-aminopyrimidinone 9

Cat #: N-310
Type: Small Molecules | SourceSynthetic | MW: 303.4 | 

Target: NaV1.7 channels

 

Ganaxolone

Cat #: G-120
Type: Small Molecules | SourceSynthetic | MW: 332.5 | 

Target: GABA(A) receptors

 


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