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[ MCE (MedChemExpress) ] New Products_New Small Molecules for January 2020

관리자 2020.01.06 21:28 조회 13


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MedChemExpress (MCE) offers a wide range of high quality research chemicals and biochemicals including novel bioactive compounds, dye reagents, peptides and natural compounds for laboratory and scientific use.
•  Over 15,000 bioactive molecules in stock •  High purity & competitive prices
•  Target 375 key proteins in 20 signaling pathways •  Data sheet with detailed biological information
•  Quality reports (LC/MS, NMR and HPLC) for each product •  Delivery within 24 hours
•  Release more than 500 of the newest biochemicals per month  
• MAPKAPK2 (MK2) Inhibitor
PF-3644022

CAS No. : 1276121-88-0

PF-3644022 is a potent, selective, orally active and ATP-competitive MAPKAPK2 (MK2) inhibitor with an IC50 of 5.2 nM and a Ki of 3 nM. PF-3644022 also inhibits MK3 and p38 regulated/activated kinase (PRAK) with IC50s of 53 nM and 5.0 nM, respectively. PF-3644022 potently inhibits TNFα production and has anti-inflammatory effect.

• Protease-Activated Receptor (PAR) Antagonist
SCH79797 dihydrochloride

CAS No. : 1216720-69-2

SCH79797 dihydrochloride is a highly potent, selective nonpeptide protease activated receptor 1 (PAR1) antagonist with an IC50 of 70 nM.

• NO Synthase Inhibitor
AR-C102222 hydrochloride 

CAS No. : 1781934-50-6

AR-C102222 hydrochloride is a potent, competitive, orally active and highly selective inducible nitric oxide synthase (iNOS) inhibitor, with an IC50 of 37 nM. AR-C102222 hydrochloride has antinociception and anti-inflammatory activity.

• Motilin Receptor Antagonist
MA-2029

CAS No. : 287206-61-5

MA-2029 is a selective, orally active, and competitive motilin receptor antagonist (IC50=4.9 nM).

• CCR Antagonist
C-021

CAS No. : 1784252-84-1

C-021 dihydrochloride is a potent CC chemokine receptor-4 (CCR4) antagonist. C-021 dihydrochloride potently inhibits functional chemotaxis in human and mouse with IC50s of 140 nM and 39 nM, respectively.

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Other New Products This Month

CY 208-243 (Dopamine Receptor) | NS5806 (Potassium Channel) | FPA-124 (Akt) |
PF-06882961 (Glucagon Receptor) | NTP42 (Prostaglandin Receptor) | Mifobate (PPAR) |
PF-00356231 hydrochloride (MMP) | GR 103691 (Dopamine Receptor) | Prinomastat (MMP) |
CYM 9484 (Neuropeptide Y Receptor) ...