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rapidly growing product range for understanding CD8+ and CD4+ T cell responses to CoVID-19/SARS-CoV-2
ProImmune provided CoVID-19/SARS-CoV-2 Pro5® MHC Pentamers and peptides for the identification and characterization of SARS-CoV-2 specific T cell responses in convalescent patients, which has now resulted in the following key new early collaborative publication by an international team in China and the UK including Oxford University and ProImmune:
Peng Y., Dong T., et al. (2020) "Broad and strong memory CD4+ and CD8+ T cells induced by SARS-CoV-2 in UK convalescent individuals following COVID-19"
Nature Immunology (2020)
https://doi.org/10.1038/s41590-020-0782-6
Figure. Examples of peptide - MHC class I Pro5® MHC Pentamer staining ex vivo, with PBMCs (HLA-B*07:02/SPRWYFYYL, B*40:01/MEVTPSGTWL, A*11:01/KTFPPTEPK, A*01:01/FTSDYYQLY and A*02:01/YLQPRTFLL) or with cultured cell lines (HLA-A*0301/KTFPPTEPK). Datasets provided by Peng Y. from the study now published in Nature Immunology (2020).
Pro5® Pentamer
ProT2® Tetramer
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