recombinant high-performance binding reagents beyond antibodies
New and expanding target areas:
27 MHC-peptide specificities targeted
13
Anti-therapeutic antibody idiotypes
Bovine
IgG subtype specific
CAS
enzyme specific products
(CAS9,
CAS12, CAS Phi)
Viral
proteins:
(HIV,
HCV, EBV, Flu, RSV, SIV, SARS-CoV-2, Zika, Dengue, WnV,
RVFV)
and
many more
Cytokines,
CD markers, growth factors, cell-signaling pathway proteins
see
the full Ankyron Catalog here
Dear
Researchers,
A new era of target-binding
reagents beyond antibodies is beginning:
Ankyrons™ are next-generation target binding
reagents provided by ProImmune that overcome many of the current
constraints of research antibodies. They offer affordable
high-quality customized recombinant monoclonal binding reagents for any
application and protein target.
Ankyrons disconnect from the animal-immune
response paradigm of antibodies as binding reagents.
Figure
1: Domain comparison between Ankyons and Antibodies.
All Ankyrons are based on single domain
ankyrin-repeat scaffold, selected in
vitro by ribosome display for medium to
high affinity from ProImmune’s synthetic Ankyron Teralibrary™ of around one billion (~1012) clones. Therefore Ankyrons™
are by default recombinant sequence defined target binding molecules, unlike
standard monoclonal antibodies. The exceptionally large starting clone number
in our Teralibrary™ makes selecting Ankyrons
more efficient than selecting antibody fragments from comparable antibody
screening libraries in
vitro. Ankyrons can be directly labelled or detected via
an epitope or biotin tag. Ankyrons can be engineered to combine them with
further Ankyron or other domains much more easily than
even recombinant Antibodies. Unlike Antibodies, Ankyrons do not have isotypes or any species
origin.
Ankyron™
features
·Always recombinant, monoclonal, sequence
defined by default
·Selected entirely in vitro from our Teralibrary™ for higher affinity
·Unconstrained by immunological tolerance
·Superior single domain properties
compared to antibodies
·Fast, inexpensive, customization with
affinity tags and labels for every order
·Rapidly growing catalog range to very
wide range of targets and target areas
·Custom recombinant monoclonal generation
for any budget*
·Further formatting to order as
multi-specifics and multivalent molecules available
·More cost-effective than research
antibody technology in every respect
·Generated without animal immunization
·Distinguish closely related proteins with
Ankyron guided selection
·For research applications, including:
flow cytometry, ELISA, western blotting, immunohistochemistry,
immunoprecipitation, cell culture and more
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