The EDI™ Human Osteocalcin (1-43/49) Specific ELISA Kit is useful for assessing the bone formation activity or osteoblast activity in patients associated with changes in the rate of bone turnover in metabolic bone disease, such as osteoporosis, primary hyperparathyroidism, hyperthyroidism, Paget’s disease, and renal osteodystrophy. In a clinical setting, an abnormally high Gla-Osteocalcin indicates active loss of bone mass, which may trigger anti-bone re-absorption treatment medication such as Alendronate. Our kit measures Gla-Octeocalicn (1-43/49) or fully carboxylated osteocalcin, while other IVD osteocalcin tests cannot differentiate Gla-Oc versus ucOC (un-carboxylated OC). Because of this, our kit is the most precise, specific and sensitive assay in clinical assessment of bone turnover in osteoporosis.